Prof. Gerard Roelfes (RUG) and coworkers publish an article in Nature Chemistry on the creation of designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue. The incorporation of an unnatural amino acid that feature unique reactive side chains significantly expand the catalytic repertoire of designer enzymes. This facilitates an ideal starting point for future efforts that will focus on exploring directed evolution strategies.
The full article can be found here. Moreover, please find an article on the NEMO-Kennislink website about the topic here (in Dutch).
