Dr. Christian Ottmann, Prof. Luc Brunsveld, and coworkers from the Eindhoven University of Technology, in collaboration with researchers from McGill University in Montreal (Canada) have taken an important step towards developing a drug against cystic fibrosis. In people suffering from this illness the CFTR protein is not located in the right place in mucus-producing cells: it remains inside the cell while it should be in the cell wall. Those cells secrete a tough mucus with serious consequences. However, the researchers have succeeded in conducting the CFTR to the cell walls. Their findings are published this week in the leading science journal PNAS.
Check here the full press release by the the Eindhoven University of Technology.
Loes M. Stevers, Chan V. Lam, Seppe F. R. Leysen, Femke A. Meijer, Daphne S. van Scheppingen, Rens M. J. M. de Vries, Graeme W. Carlile, Lech G. Milroy, David Y. Thomas, Luc Brunsveld, and Christian Ottmann. Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR, PNAS (2016), doi: 10.1073/pnas.1516631113